biosensor reader

Real-time biosensor reader is an advanced analytical platform designed specifically for automated, non-invasive, and continuous monitoring of microfluidic environments. By integrating triple-parameter sensing—pH, Glucose, and TEER (Transepithelial/Transendothelial Electrical Resistance)—into a single compact device, this reader provides researchers with immediate, actionable data on tissue viability, barrier integrity, and metabolic activity directly from their Organ-on-a-Chip platforms.

Continuous, Non-Invasive Metabolic and Structural Tracking

Traditional end-point analysis requires destroying the tissue sample or pausing the experiment to manually collect media. The B5tec Biosensor Reader eliminates these limitations. It offers fully automated, inline sensing that tracks the physical and chemical evolution of your cellular models in real time, allowing for long-term validation without disrupting the closed-loop microfluidic environment.

Core Tracking Metrics for Advanced In-Vitro Models

• TEER (Barrier Integrity): Quantify cellular confluence and tight junction formation with automated, non-destructive TEER measurements. Ideal for monitoring endothelial and epithelial barrier models (such as Skin-on-a-Chip or Blood-Brain Barrier models) in real-time.

• Glucose Consumption (Metabolic Activity): Track glucose depletion levels directly within the microfluidic channel. This metric offers an accurate, live read on cellular metabolism, proliferation, and responses to drug compounds.

• pH Stability (Microenvironment Health): Monitor subtle shifts in extracellular pH. Immediate detection of pH changes acts as an early warning system for metabolic stress, hypoxia, or cellular distress before visible morphology changes occur.